The Prime Minister of Malta is the most powerful figure within the government of Malta, although the President of Malta has higher rank. The Prime Minister is appointed by the President, with the President making his or her decision based on the situation within the Maltese parliament. A Prime Minister must command a majority of the votes in parliament to hold office.

Twelve people have served as Prime Minister of Malta since the office was established in 1921. The post did not exist in the period between 1933 and 1947 or the period between 1958 and 1962.

	Name	Took Office	Left Office	Party
1	Joseph Howard	1921	1923	Popular Union
2	Francesco Buhagiar	1923	1924	Popular Union
3	Ugo Pasquale Mifsud , 1st time	1923	1927	Nationalist Party
4	Gerald Strickland	1927	1932	Constitutional Party
	Ugo Pasquale Mifsud , 2nd time	1932	1933	Nationalist Party
Office Abolished
5	Paul Boffa	1947	1949	Labour Party
	Paul Boffa , continued	1949	1950	Worker's Party
6	Enrico Mizzi	1950	1950	Nationalist Party
7	George Borg Olivier, 1st time	1950	1955	Nationalist Party
8	Dom Mintoff, 1st time	1955	1958	Labour Party
Office Abolished
	George Borg Olivier, 2nd time	1962	1971	Nationalist Party
	Dom Mintoff, 2nd time	1971	1984	Labour Party
9	Carmelo Mifsud Bonnici	1984	1987	Labour Party
10	Eddie Fenech Adami, 1st time	1987	1996	Nationalist Party
11	Alfred Sant	1996	1998	Labour Party
	Eddie Fenech Adami, 2nd time	1998	2004	Nationalist Party
12	Lawrence Gonzi	2004	Present	Nationalist Party