The year 1880 in science and technology included many events, some of which are listed here.

Awards

• Copley Medal: James Joseph Sylvester
• Wollaston Medal: Auguste Daubree

Births

• January 18 - Paul Ehrenfest (d. 1933), Austrian physicist and mathematician.

Deaths

• July 9 - Paul Pierre Broca (b. 1824), anthropologist.