The term Spitfire can refer to:

• a euphemistic translation of Cacafuego, a Spanish treasure galleon captured by Sir Francis Drake,
• a warplane, see Supermarine Spitfire
• a ship, see HMS Spitfire
• a movie from 1934, see Spitfire (1934)
• The US title of the British 1942 film The First of the Few.
• a movie from 1994, see Spitfire (1994)
• an car from Triumph Motor Company, see Triumph Spitfire
• a garage rock band from the UK, see Spitfire_(band)
• a ska band from Saint Petersburg, see www.spitfire.spb.ru
• Spitfire Records , a heavy metal-oriented record label
• a UK bottled and cask beer.
• Slang: A highly-excitable or passionate person. Actress Lupe Velez was known as "the Mexican spitfire".
• a BBS software program, see Spitfire (BBS)
• a skateboard-wheel company.
• a caterpillar found in Australia, see spitfire (caterpillar) .