PE or Pe may stand for:

• Pe is one of the transliterations of the fourth syllable in Buddhist "Six syllable mantra" Om mani padme hum.
• Pe (letter), a letter of the Cyrillic alphabet
• The letter Pe in the Hebrew alphabet
• PE ratio - price-to-earnings ratio (used in finance)
• Peru (ISO 3166-1 alpha-2 country code)
• Physical education
• Parasite Eve
• Polyethylene (PE) a common plastic polymer
• Portable Executable file format
• Prince Edward Island (Canadian province)
• Professional Engineer
• Pacific Electric Railway (AAR reporting mark PE)
• pulmonary embolism
• Public Enemy (Rap group)
• Private Eye, a character class in the MMORPG Neocron
• Pain Easer, a rare weapon in MMORPG Neocron