Madonna is Italian for "My lady". Its historical usage refers to the Mary, the mother of Jesus. The pop singer Madonna repopularized the term in the 20th century.

Madonna can refer to the following things:

• Mary, the mother of Jesus is frequently called Madonna.
• Madonna, American singer, actress, writer, and Censored page.
• Madonna is a term used to describe notable women, particularly in Italian Renaissance art.
• Madonna is a late 19th century painting by Edvard Munch.
• Madonna is the name of an album released by rock band ...And You Will Know Us By The Trail Of Dead
• Madonna Wayne Gacy, aka Pogo, is a member of Marilyn Manson.