The Prime Minister of Equatorial Guinea is nominally the head of government of that country, though most powers are in fact held by the president. The office was first created in 1963, when Equatorial Guinea gained autonomy from Spain. When the country became independent in 1968, the office was abolished. It was revived in 1982.

This is a list of Prime Ministers of Equatorial Guinea:

• Bonifacio Ondó Edu (15 December 1963 - 12 October 1968)
• Cristino Seriche Bioko (15 August 1982 - 4 March 1992)
• Silvestre Siale Bileka (4 March 1992 - 1 April 1996)
• Ángel Serafin Serafiche Dougan (1 April 1996 - 4 March 2001)
• Cándido Muatetema Rivas (4 March 2001 - June 15 2004)
• Miguel Abia Biteo Borico (June 15 2004 - present)