Irwin A. Rose (born 16 July 1926 in NY) is an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.

Rose received his B.S. in 1948 and his Ph.D. in biochemistry in 1952, both from the University of Chicago. He is currently a specialist at the Department of Physiology and Biophysics of the College of Medicine at the University of California, Irvine.

References

• Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP". Proc. Natl. Acad. Sci. USA 76, pp. 3107-3110.
• Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, pp. 1783-1786.

External links

• Nobel citation http://nobelprize.org/chemistry/laureates/2004/