Guthrie may refer to the following places:

• Guthrie, Oklahoma
• Guthrie, Kentucky
• Guthrie County, Iowa
• Guthrie, Texas

and to the following people

• Arlo Guthrie, folk singer.
• Malcolm Guthrie, professor of Bantu languages
• Woody Guthrie, folk singer, father of Arlo.
• Francis Guthrie, a mathematician famous for first stating the four color problem