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Dexamethasone

Dexamethasone chemical structure
Dexamethasone

9-Fluoro-11β,17,21-trihydroxy-16a-
methylpregna-1,4-diene-3,20-dione
CAS number
50-02-2
ATC code
A01AC02, C05AA09, D07AB19, H02AB02, R01AD03, S01BA01, S02BA06, S03BA01
Chemical formula C22H29FO5
Molecular weight 392.464
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Dexamethasone is a synthetic member of the glucocorticoid class of hormones. It is about 40 times stronger than hydrocortisone.

Therapeutic use

Dexamethasone is used therapeutically in many, mainly inflammatory and autoimmune conditions. It is also given to cancer patients undergoing chemotherapy, to counteract certain side-effects of their antitumor treatment. In certain forms of brain disease, e.g. brain tumours or secondaries, dexamethasone is used to counteract the development of edema, which would eventually compress other brain structures. It is present in certain eye drops.

Diagnostic use

Dexamethasone is also used in a diagnostic context, namely in its property to suppress the natural pituitary-adrenal axis. Patients presenting with clinical signs of glucocorticoid excess (Cushing's syndrome) are generally diagnosed by a 24h urine collection for cortisol or by a Dexamethasone suppression test. During the latter, a patient takes a nighttime dose of either 1 or 4 mg of dexamethasone, and the serum cortisol levels are measured in the morning. If the levels are relatively high, then the test is positive and the patient has an autonomous source of either cortisol or ACTH, indicating Cushing's disease.


Last updated: 02-08-2005 11:16:41
Last updated: 04-29-2005 16:33:15