Desiderio da Settignano (c.1430-1464) was an Italian sculptor active during the Renaissance. He came from a family of stone carvers and stone masons. His work shows the influence of Donatello, specifically his use of low reliefs.

His works include:

• The tomb of Carlo Marsuppini in Santa Croce, Florence
• Coat of Arms of the Gianfigliazzi and Minerbetti Families (c.1445-50) - stone
• Beauregard Madonna (c.1455) - marble relief
• A Little Boy (c.1455-1460) - marble bust
• Virgin and Child (c.1455-1460) - marble relief
• The Christ Child (c. 1460) - marble bust
• The Altar of the Sacrament in San Lorenzo, Florence (completed in 1461)
• Saint Jerome in the Desert (c.1461) - marble

Giorgio Vasari includes a biography of Desiderio da Settignano in his Lives of the Artists. [1]