Auntie Mame is a 1955 novel by Patrick Dennis that chronicles his madcap adventures growing up as the ward of his deceased father's eccentric sister. Although he referred to it as autobiographical, in reality the author was raised by both his parents.

The novel was adapted for the stage by authors Jerome Lawrence and Robert E. Lee. The original Broadway production starred Rosalind Russell in the title role.

In 1958, a film based on the play was released. In addition to Russell, it starred Forrest Tucker, Coral Browne , Roger Smith, Peggy Cass and Jan Handzlik . The screenplay was adapted by Betty Comden and Adolph Green, and the movie was directed by Morton DaCosta .

It was nominated for Academy Awards for Best Actress in a Leading Role (Rosalind Russell), Best Actress in a Supporting Role (Peggy Cass), Best Art Direction-Set Decoration, Black-and-White or Color, Best Cinematography, Color, Best Film Editing and Best Picture.

A musical version, entitled Mame, opened on Broadway in 1966.