Aldosterone is a steroid synthesized in the mid-section of the adrenal cortex of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. It helps regulate the body's electrolyte balance by acting on the mineralocorticoid receptor (MR).
Unlike neuroreceptor s, classic steroid receptors are located inside of cells. The aldosterone/MR receptor binds to hormone response element s (HRE) of the DNA that alter protein synthesis and the transcription of messenger RNA, including serum and glucocorticoid-induced kinase , channel-inducing factor , K-ras2A , and three subunits of the epithelial sodium channel . These genes are important for transepithelial sodium transport .
Aldosterone is synthesized in reaction to increases of angiotensin II or plasma potassium, which are present in proportion to sodium deficiencies.
Enzymes synthesize aldosterone from cholesterol in the zona glomerulosa of the adrenal cortex.
Aldosterone and the kidney
Control of aldosterone release
1. Williams JS, Williams GH. 50th anniversary of aldosterone. J Clin Endocrinol Metab. 2003 Jun;88(6):2364-72. Full text http://jcem.endojournals.org/cgi/content/full/88/6/2364 . Medline abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstra
ct&list_uids=12788829 (PMID 12788829).
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