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Yersinia pestis

Yersinia pestis is a species of rod-shaped bacterium, belonging to the family Enterobacteriaceae. It is the infectious agent of bubonic plague, and can also cause pneumonic plague and septicemic plague. All forms have been responsible for enormous mortality in many fearsome epidemics throughout Mankind's history (without treatment, 75% of all infected patients with the bubonic form die, and almost 100% with the pneumonic form), such as the Great Plague and the Black Death, the latter of which accounted for the death of approximately 25% of the European population.

The genus Yersinia is Gram negative, bipolar staining coccobacilli , and, similarly to other Enterobacteriaceae, it has a fermentative metabolism. Yersinia pestis produces a antiphagocytic slime. The organism is motile when isolated, but become nonmotile in the mammalian host.

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History

Y. pestis was discovered in 1894 by French physician and bacteriologist from the Pasteur Institute, Alexandre Yersin, during an epidemic of plague in Hong-Kong. Yersin was a member of the "Pasteur school". Shibasaburo Kitasato, a Germany-trained Japanese bacteriologist who belonged to the rival "Koch school" was also engaged at the time in finding the causative agent of plague. However, it was Yersin who actually linked plague with Yersinia pestis. This was originally called Pasteurella pestis, and was renamed after Yersin.

Pathogenicity and immunity

Pathogenicity is due to two antiphagocytic antigens, named F1 and VW, both required for virulence. They are produced by the bacterium at the temperature of 37C, so this explains why insects, such as the flea, harbor non-virulent bacteria. Furthermore, Y. pestis survive and produce F1 and VW antigens within blood cells such as monocytes, but not in polymorphonuclear neutrophils. Natural or induced immunity is achieved by the production of specific opsonic antibodies against F1 and VW antigens. They induce phagocytosis neutrophils.

There is a formalin-inactivated vaccine available for adults at high risk, but it is not very effective and may cause severe inflammatory reactions. Experiments with genetic engineering of a vaccine based on F1 and VW antigens is underway and shows great promise.


Genome

The genome of the CO92 strain obtained from clinical isolate from the USA was recently sequenced. The chromosome sequence is 4,653,728 base pairs long.

Susceptibility

Y. pestis is highly susceptible to several antibiotics, mainly streptomycin and chloramphenicol.

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Last updated: 08-29-2005 02:36:49
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