Urease (EC 22.214.171.124) is an enzyme that catalyzes the hydrolysis of urea into carbon dioxide and ammonia. The reaction occurs as follows: (NH2)2CO + H2O → CO2 + NH3
In 1926 James Sumner shows that urease is a protein. Urease is found in bacteria, yeast and several higher plants.
A specific urease (which may be used in diagnosis) occurs in Helicobacter pylori.