USS St. Louis has been the name of six ships in the United States Navy. All were named for the city in Missouri.

• The first St. Louis was a sloop-of-war commissioned in 1828.

• The second St. Louis was a gunboat later renamed Baron de Kalb during the American Civil War.

• The third St. Louis was a transatlantic passenger liner, charter for Naval service during the Spanish-American War. Later renamed Louisville (SP-1644).

• The fourth St. Louis served during World War I.

• The fifth St. Louis served during World War II.

• The sixth St. Louis was decommissioned in 1992.