Trophimus, meaning a foster-child, was an Ephesian who accompanied Paul during a part of his third missionary journey (Acts 20:4; 21:29). He was with Paul in Jerusalem, and the Jews, supposing that the apostle had brought him with him into the temple, raised a tumult which resulted in Paul's imprisonment. (See Herod's Temple). In writing to Timothy, the apostle says, "Trophimus have I left at Miletus sick" (2 Tim. 4:20). This must refer to some event not noticed in the Acts.

See also: Trophimus of Arles, ('Saint Trophime'), the first bishop and patron saint of Arles, 3rd century CE.