The Man with Two Brains is a 1983 US film directed by Carl Reiner and starring Steve Martin and Kathleen Turner.

Written by Martin and George Gipe the film is a broad comedy. Martin plays Dr. Michael Hfuhruhurr, a pioneering neurosurgeon with a cruel and unfaithful new wife, Dolores Benedict (Kathleen Turner).

Hfuhruhurr saves the life of Benedict, who was injured in a car accident. As she recovers Hfuhruhurr falls in love with her and they marry. She is only interested in his wealth. On a honeymoon/business trip to a medical conference in Vienna, a city living in fear of the serial "Elevator Killer", Hfuhruhurr leaves his wife and meets mad scientist Dr. Alfred Necessiter (David Warner) who has created a radical new technique, storing living brains in liquid-filled jars.

Hfuhruhurr discovers he can communicate telepathically with one of the brains, that of Ann Uumellmahaye (voiced by Sissy Spacek). The two immediately fall in love. The confluence of a spate of random murders and the possibility of brain transplantation causes Hfuhruhurr to speculate about how he might improve his lot in life...