The Greene Murder Case is a 1928 mystery novel by S. S. Van Dine. It focuses on the murder one by one of the Greene family: "The holocaust that consumed the Greene family", as Philo Vance memorably puts it. This book contains S. S. Van Dine's greatest ingenuity as a puzzle plot constructor, containing a number of clever ideas.

It also completes a trilogy. The Benson Murder Case focused on the death of a single man, who lead a public life and was involved in business; The Canary Murder Case focused on a couple and romantic love; and The Greene Murder Case focused on a family. The three books together have a powerful cumulative impact, their imagery bringing a tragic focus to basic human institutions.