The position of Secretary of State for Dominion Affairs was a British cabinet level position created in 1925 to deal with British relations with the Dominions — Canada, Australia, New Zealand, South Africa, Newfoundland, and the Irish Free State. In 1947, the name of the office was changed to the Secretary of State for Commonwealth Relations. In the early years of the position, it was frequently held by the same person who held the office of Secretary of State for the Colonies.

Secretaries of State for Dominion Affairs, 1925-1947

• Leo Amery (June 11, 1925 - June 4, 1929)
• Sidney James Webb, 1st Baron Passfield (June 7, 1929 - June 5, 1930)
• James Henry Thomas (June 5, 1930 - November 22, 1935)
• Malcolm MacDonald (November 22, 1935 - May 16, 1938)
• Edward Montagu Cavendish Stanley, Lord Stanley (May 16, 1938 - October 31, 1938)
• Malcolm MacDonald (October 31, 1938 - January 29, 1939)
• Sir Thomas Walker Inskip (January 29, 1939 - September 3, 1939)
• Anthony Eden (September 3, 1939 - May 14, 1940)
• Thomas Inskip, 1st Viscount Caldecote (May 14, 1940 - October 3, 1940)
• Robert Arthur James Gascoyne-Cecil, Viscount Cranborne (October 3, 1940 - February 19, 1942)
• Clement Attlee (February 19, 1942 - September 24, 1943)
• Robert Arthur James Gascoyne-Cecil, Viscount Cranborne (September 24, 1943 - July 26, 1945)
• Viscount Addison (August 3, 1945 - July 7, 1947)