Samuel Tuke (July 31, 1784 - October 14, 1857), son of Henry Tuke was born at York.

He greatly advanced the cause of the amelioration of the condition. of the insane, and devoted himself largely to the York Retreat, the methods of treatment pursued in which he made more widely known by his Description of the Retreat near York, etc. (York, 1813).

He also published Practical Hints on the Construction and Economy of Pauper Lunatic Asylums (1815).

His two sons James Hack Tuke and Daniel Hack Tuke were also active in humanitarian concerns.