SAM is an acronym for:

• S.A.M.
• Scheduled Ancient Monument
• Self-assembled monolayer
• Sociedad Aeronáutica de Medellín - a Colombian airline.
• Software Automatic Mouth
• Spatial access method
• Student Association of Missouri
• Surface-to-air missile
• System Account Manager
• Sam and Max
• Sensitron Application Module
• Seattle Art Museum

SAM was also the name of the robot mascot used in advertising the SAM Coupé.