Pruneface was a villainous character in the long-running comic strip Dick Tracy, drawn by cartoonist Chester Gould.

Pruneface was brilliant industrial engineer who had a horribly deformed face, which had led to social rejection and apparently so poisoned his mind that he sold out to the Nazis and was involved in the development of nerve gas. After the character's story arc in the comic strip ended, he was revived for the animated version which aired intermittently in the U.S. as a children's program, primarily in the 1960s.

He also made a brief appearance in the Dick Tracy movie starring Warren Beatty, largely to showcase the prowess of the movie's prosthetic makeup team.