Presque Isle is the name of several places in the United States of America. The name means almost an island in archaic French; presumably the places of that name are located on peninsulas.

• Presque Isle (Pennsylvania) is a cape on Lake Erie and state park near the city of Erie, Pennsylvania
• Presque Isle, Wisconsin, a town
• Presque Isle, Maine, a town
• Presque Isle County, Michigan
• Presque Isle Township, Michigan
• Presque Isle River , a river in Michigan
• Presque Isle Point is a cape on Lake Superior near the city of Marquette, Michigan

There is also the Presquile National Wildlife Refuge on the James River in Virginia