The Popular Front for the Liberation of Palestine - General Command is a left-wing Palestinian nationalist organization. The group was founded in 1968 as a splinter group from the PFLP. Ahmed Jibril, one of the PFLP's early leaders, broke away to form the PFLP-GC. The new group initially declared that its focus would be military, not political.

Although the group was initially a member of the Palestine Liberation Organization, it has always opposed Yasser Arafat and opposes any political settlement with Israel; as such, it has never participated in the peace process. Both the PFLP-GC and PFLP left the PLO in 1974 to oppose what they saw as the PLO's move towards an accommodation with Israel.

The PFLP-GC has been designated a terrorist organization by the United States and the European Union.