Menkheperre was the high priest of Amun at Thebes in Ancient Egypt 1045 BC to 992 BC and de facto ruler of the south of the country.

With his elder brother ruling at Tanis as Pharaoh Psusennes I , Menkheperre's power, like that of his predecessor as high priest, his brother Masaherta , must have been somewhat curtailed. Menkheperre took as his throne name the title of "first prophet of Amun", just as his great-grandfather Herihor had, perhaps an indication of this diminished role, though he kept the cartouche unlike his successors in the temple.

Menkheperre was succeeded by his son Smendes II , also called Nesbanebjed II.