Fulvius Macrianus (died 261), also known as Macrianus Major to distinguish him from his son Macrianus Minor, was disqualified from the imperial office because of his lameness, but with support from Ballista, Roman emperor Valerian's praefect, he had his two sons Macrianus Minor and Quietus elevated to the throne.

He was one of Valerian's generals and a man who possessed vast wealth. His wife was of noble birth, he himself merely brave.

After Valerian's capture and execution by the Sasanid Persians in 260, Macrianus marched his army from Asia to Europe but was defeated in Thrace in 261 by emperor Gallienus' general Aureolus. Macrianus and his son were killed. Quietus was later murdered by Odaenathus of Palmyra.