Ma Perkins (sometimes called Oxydol's Own Ma Perkins) was a radio serial which was heard in America on NBC from 1933 to 1949 and on CBS from 1942 to 1960. Between 1942 and 1949, the show was heard simultaneously on both networks. Oxydol dropped its sponsorship in 1956.

The show ran for 7,065 episodes and Ma Perkins was played the entire time by actress Virginia Payne. The character owned and operated a lumber yard in the small town of Rushville Center. The drama which resulted between her interactions with townsfolk, as well as the dilemmas of her three children, were much of the stories in the serial.

When the show finally ended the day after Thanksgiving Day, 1960, it was one of only eight entertainment shows still on the CBS radio network.