Many makes and models of microcomputers could run, or ran from the outset, some version of the CP/M operating system. The following is an alphabetical list of some of those computers:

• ABC-24
• MITS Altair 8800
• Altos 580
• Amstrad CPC 464 (w/ DDI-1 disk drive interface)
• Amstrad CPC 6128    (and 664)
• Amstrad PCW 8256/8512/9512
• Amust Executive 816
• Apple II (with Microsoft Z80 Softcard)
• Aster CT-80
• Atari ST
• BBC Micro (with external Z80 module)
• Beehive Topper II
• Bigboard
• BMC IF800
• Bondwell 12, 14, 16
• Casio FP1000 FL
• Commodore 64 (with an infamously poor Z80 plug-in cartridge)
• Commodore 128
• Compis
• Compupro
• Cromemco
• Datamax UV-1R
• DEC Rainbow 100/100+
• DEC VT-180 (aka Personal Computing Option, aka 'Robin')
• Epson PX-4, PX-8 (Geneva), QX-10, QX-16
• Exidy Sorcerer
• Heath/Zenith H90 and H89
• Hewlett-Packard HP-100
• Hobbit
• IBM PC
• IMSAI 8080
• Intel MDS-80
• Intertec Superbrain QD
• Iotec
• Kaypro
• LOBO Max-80
• MCP (128K, Z80, S-100 bus)
• Applied Technology Microbee (56KB+ RAM models)
• Mycron 3
• NCR Decision mate V
• NEC APC
• NEC PC-8800
• Northstar Horizon
• Osborne 1
• Osborne Vixen
• Otrona Attache
• Philips P2000T
• Processor Technology Sol-20 (optional)
• Research Machines 380Z and Link 480Z
• Sanyo MBC-1150
• Scandis
• ZX Spectrum +3
• Tandy TRS-80 model 4
• Televideo TS-802H
• Xerox 820
• Yodobashi Formula-1
• Zenith Electronics Corporation Z-100
• Zorba