Herbert A. Hauptman is an American mathematician and Nobel laureate.

He was born in New York City on 14 February, 1917, the oldest child of Israel Hauptman and Leah née Rosenfeld.

He was interested in science and mathematics from an early age, graduated from the City College of New York (1937) and obtained an M.A. degree in mathematics from Columbia University in 1939.

After the war he started a collaboration with Jerome Karle at the Naval Research Laboratory in Washington, D.C. and at the same time enrolled in the Ph.D. program at the University of Maryland. This combination of mathematics and physical chemistry expertise enabled them to tackle head-on the phase problem of X-ray crystallography. By 1954 he had received his Ph.D. and they had laid the foundations of the direct methods in X-ray crystallography. Their 1953 monograph, "Solution of the Phase Problem I. The Centrosymmetric Crystal", contained the main ideas, the most important of which was the introduction of probabilistic methods.

In 1970 he joined the crystallographic group of the Medical Foundation of Buffalo of which he was Research Director in 1972. During the early years of this period he formulated the neighborhood principle and extension concept. These theories were further developed during the following decades.

He has received many awards including the 1985 Nobel Prize in Chemistry jointly with Jerome Karle. He is married, with two daughters.