The Grammy Award for Best Instrumental Performance was awarded from 1965 to 1968. The award had several minor name changes:

• From 1965 to 1966 the award was known as Best Instrumental Performance - Non-Jazz
• In 1967 it was awarded as Best Instrumental Performance (Other Than Jazz)
• In 1968 it was awarded as Best Instrumental Performance

Although in the "pop" field the award did not specify pop music performances. Since 1969 a pop-specific award has been presented for Best Pop Instrumental Performance.

Years reflect the year in which the Grammy Awards were presented, for works released in the previous year.

1960s

• Grammy Awards of 1968
  • Chet Atkins for Chet Atkins Picks the Best
• Grammy Awards of 1967
  • Herb Alpert for "What Now My Love" performed by Herb Alpert & the Tijuana Brass
• Grammy Awards of 1966
  • Herb Alpert for "A Taste of Honey" performed by Herb Alpert and the Tijuana Brass
• Grammy Awards of 1965
  • Henry Mancini for "The Pink Panther Theme"