Flavia Domitilla was the name shared by the wife, daughter and granddaughter of the Roman Emperor Vespasian.

The eldest Flavia Domitilla was Vespasian's wife. She was the daughter of Flavius Liberalis , a humble quaestor and later clerk. Before her marriage, she was a formal mistress to an African knight. She and Vespasian married around AD 38. She was the mother of Domitilla (see below) and the emperors Titus and Domitian. She died before Vespasian assumed the purple.

Her daughter Flavia Domitilla, called Domitilla, was Vespasian's only daughter. She was born in AD 39 and died around the same time as her mother.

Domitilla's daughter, whose father is unknown, was also named Flavia Domitilla. She married her cousin, the consul Titus Flavius Clemens , whom Domitian executed for complicity in Nero's death. She had two sons by him, whom Domitian made his own heirs. Her steward assisted in Domitian's assassination.