Ephraim can refer to:

1. The Biblical patriarch Ephraim and his descendents, the Tribe of Ephraim
2. Saint Ephraim the Syrian
3. Mount Ephraim
4. Wood of Ephraim
5. Ephraim in the wilderness
6. The Book of Ephraim by James Merrill
7. A character from the Fire Emblem series, more specificially Fire Emblem: Seima no Kouseki. See Ephraim (Fire Emblem)