Dynorphin is a popular and powerful opioid ligand. It may act as an antidote to pleasurable effects of cocaine. As such, it may help some individuals against the trap of addiction. Blocking it may help alleviate depression.

References

"Dynorphin and Depression." Opioids.com. Accessed on March 4, 2005.

"Dynorphin: Nature's Own Antidote to Cocaine (and Pleasure?)." dynorphin.com. Accessed on March 4, 2005.