Duke is a title of nobility given to some people:

• Duke

Duke is the nickname of some people in the United States of America:

• John Wayne (known as "The Duke")
• Raoul Duke , alter-ego to Hunter S. Thompson
• Uncle Duke, a character from the Doonesbury comic strip by Garry Trudeau based on Raoul
• Duke Ellington, a jazz musician

Duke is also the name of a university in the United States: Duke University.

The Duke was the name of two television series

• one in 1954 The Duke (TV series)
• one in 1979 The Duke (TV miniseries).

The Dukes of Hazzard produced an animated spin-off called The Dukes.

Duke is the mascot of the Java programming language