Drug-free school zone is a term used in the United States to denote an area within a certain distance, most commonly 1,000 feet, of the nearest school. Signs to this effect are generally posted along all public streets at the entrances to such an area.

The term is somewhat misleading, in that the sale or even possession of recreational drugs is uniformly illegal throughout the United States; what does make the signs relevant, however, is that the laws in most American states now call for increased criminal penalties for any drug sales (and, in some of these states, possession of drugs in sufficient quantity as to suggest an obvious intent to sell on the part of the person possessing said drugs) that occur within the designated zone. The first laws of this kind were passed in the late 1980s.