Dniprodzerzhynsk (Ukrainian: Дніпродзержинськ, Dniprodzerzhyns'k; Russian: Dneprodzerzhinsk, formerly Kamenskoye) is a city in Dnipropetrovsk Oblast of Ukraine, a port on the Dnieper river.

Leonid Brezhnev was born in Dniprodzerzhynsk.

In 1996, a tram derailed on one of the city's streets causing dozenes of deaths. That accident has had a significant effect on the worldwide discussion regarding use of trams in the hilly localities.