Dimitrie Ghica (1816-1897) was the Prime Minister of Romania as a representative of the Conservative Party between 1868 and 1870.

He was born in the Ghica family, as the son of the Wallachian voivode Grigore Dimitrie Ghica . (1755-1834), by his first wife, Maria Hangerly. He married Charlotte Duprond, and they had two daughters, Maria and Iza.