Desoxyn&reg CII is a pharmaceutical form of methamphetamine hydrochloride (also known as desoxyephedrine, hence the name "Desoxyn"), indicated for treatment of Attention Deficit Disorder/Attention Deficit/Hyperactivity Disorder (ADD/ADHD), narcolepsy, and exogenous obesity. Desoxyn is a Schedule II medication under the U.S. DEA Schedule system, and is a member of the amphetamine class of stimulants.

Desoxyn was manufactured and marketed by Abbott Laboratories as both an immediate-release tablet and a sustained-release Gradumet formulation (in the form of a plastic-matrix tablet). Abruptly, however, Abbott discontinued production of the Gradumet form of Desoxyn in Fall, 1999, citing "manufacturing difficulties" as the reason for discontinuation.

In 2002, Abbott sold their rights to Desoxyn to Ovation Pharma, which took over production and marketing of the drug. In addition, Able Labs produces a generic formulation of methamphetamine at a lower price than brand-name Desoxyn.

Because methamphetamine, the active ingredient in Desoxyn, is reported to be effective longer and fifty percent more effective per dose than amphetamine, for example, prescriptions for this drug may increase as ADD/ADHD treatment increases and as long-term users of other treatments gain tolerance to the other stimulant drugs used to treat ADD/ADHD.

As a pharmaceutical-grade form of methamphetamine, which has gained a reputation for abuse, Desoxyn has retained a degree of controversy because of concerns it may be abused. However, the tablet form of Desoxyn cannot effectively be smoked, snorted or injected, and many patients treated with Desoxyn report the benefits to exceed that of related treatments such as Ritalin/methylphenidate or Adderall/amphetamine. Further, research has indicated that ADD/ADHD patients treated with stimulants are in fact less likely to abuse substances than patients who are not treated with these drugs, and there is little evidence that prescription stimulant use under a medical program administered by a doctor leads to abuse.