Def Jam Vendetta is a video game for the PlayStation 2. The player controls a newly-formed organization that participate in organized gang fights. Its story mode involves fighting various mobs controlled by urban figures such as DMX, Method Man, and Redman. The objective of the game is to reach D-mob, your rival mob, and defeat it. The game was produced by Arso Robinson .

Vendetta was followed by a sequel in 2004 called Def Jam Fight for NY .