Antonia (30 -66 AD) was Claudius' only child to his second marriage to Aelia Paetina. Until 37 AD, she was raised by her grandmother Antonia Minor. From then until 43 AD, she was raised by her father.

In 43 AD, in an arranged marriage she first married Gnaeus Pompeius Magnus, a man of the highest birth. According to Suetonius he was murdered several years later, because he was caught in bed with his favourite boyfriend. However Cassius Dio states that Messalina (out of her fear, of Pompeius being a rival to Britannicus) ordered his execution, so that Antonia could marry Messalina's half-brother to strengthen the Julian blood-line. His name was Faustus Cornelius Sulla Felix.

Faustus Sulla and Antonia married later that year. They had a son, who lived up to his second birthday. The child was a weak one of little strength.

In 58 AD, Faustus Sulla was exiled and murdered in 62ad on Nero's orders. Antonia in 65 AD, participated in the failed revolt of Gaius Calpurnius Piso. Tacitus stated that Antonia would marry Piso, if he became Emperor. However Tacitus was not sure if this proposal was a rumour or fact.

After the death of Empress Poppaea Sabina, Nero asked her to marry him. When Antonia refused, Nero charged on attempt of rebellion and executed her.

With the death, she was the last living grandchild of Nero Claudius Drusus and Antonia Minor.