Clarence E. "Big House" Gaines (b. May 21, 1923 in Paducah, Kentucky - d. April 18, 2005 in Winston-Salem, North Carolina) was a former college men's basketball coach. He coached at Winston-Salem State University from 1946 to 1993, compiling a 828-447 record. Among his former players is fellow Hall of Famer Earl Monroe and noted commentator and columnist Stephen A. Smith .

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