Christina of Lorraine or Chretienne de Lorraine (16 August 1565 - 19 December 1637), born in Nancy, was the daughter of Charles II of Lorraine (1543-1608) and his wife Claude of France (1547-1575).

On 3 May 1589 she married Ferdinando I de Medici , Grand Duke of Tuscany, thereby becoming Grand Duchess Christina of Tuscany. Their son, Cosimo II de Medici succeeded his father as Grand Duke.

Galileo wrote his Letter to Grand Duchess Christina, expounding on the relationship between science and revelation, in 1615.

She died in Florence at the age of 72.