Brenda Vaccaro (born November 18, 1939 in Brooklyn, New York) is a American stage, motion picture, and television actress.

Vaccaro was nominated for an Academy Award for Best Supporting Actress and won the Golden Globe for her performance in the 1975 film Jacqueline Susann's Once Is Not Enough . An accomplished performer in live theatre, Brenda Vaccaro has been nominated for three "Best Actress" Tony Awards for her work on Broadway.