Bonifacio Ondó Edu (d. 1969) was the prime minister of Equatorial Guinea while it was still under Spanish colonial rule. He took office when the country gained autonomy in 1963 and handed power to President Francisco Macías Nguema on 12 October 1968 (the day of independence). Ondó "committed suicide" while in prison for political crimes; however, the actual cause of his death will probably never be known.