The Bay of Campeche (Spanish: Bahía de Campeche) is the southern bight of the Gulf of Mexico. It is surrounded on three sides by the Mexican states of Campeche, Tabasco and Veracruz.

The Cantarell Complex of five oil fields lies beneath the Bay of Campeche. It is the second most productive oil field in the world, supplying about two thirds of Mexico's crude oil output.