Ayako is the name of a manga trilogy by Osamu Tezuka.

The story is about a post-world-war-II Japanese family that has to cope with economic and family tensions. Jiro, one of the eldest sons, has become an agent working for the US and he is surprised in his secret killings by Ayako, his youngest sister. This problem is only more aggravated by the fact that she discovers terrible incestuous affairs in her own family, where it is found out that her elder sister is actually her mother who has to frequently have sex with her own father, Sakuemon. The family, under the pressure of Sakuemon and Ichiro the eldest son, wants to stay out of trouble and decides to keep Ayako locked up in the basement during her whole life.

Despite the efforts of her mother and youngest son Shiro, she will grow dozens of years under the family's house, while great political and social berserk goes around. Ayako eventually leaves the basement after she grew into a beautiful and attractive woman, seeking affection from close people and yet still terrified by the outside world.