In medicine, the atopic syndrome is the clustering of eczema, allergic conjunctivitis, allergic rhinitis and asthma in certain individuals. There appears to be a strong hereditary component, although environmental factors have also been implicated.

Some physical attributes have been associated with atopic syndrome, although the real relationship is poorly understood:

• A skin fold under the eyes termed "Denny-Morgan folds";
• A collection of short hairs under the fringe;
• Cracks in the skin under the earlobe.