Ashikaga Yoshiakira (Jp. 足利 義詮) (July 4, 1330–December 28, 1367) was the second shogun of the Ashikaga shogunate who reigned from 1358 to 1367 during the Muromachi period of Japan. Yoshiakira was the son of the founder and first shogun of the Muromachi shogunate, Ashikaga Takauji.

Yoshiakira succeeded his father Takauji as Seii Taishogun after his death in 1358.

A year after his death, he was succeeded by his son Ashikaga Yoshimitsu as the third shogun in 1368.