Queen Ahmose-Nefertari of Egypt was the sister-wife of Egypt's Pharaoh King Ahmose I. She had two children-Amenhotep I and Aahhotep II , who wed each other and had the Princess Aahmes . Aahmes married the next Pharaoh, Thutmose I(Tuthmosis, Thothmes), a military general who succeeded the Imperial Throne of Egypt after Amenhotep I died childless. The royal couple had a daughter, the Princess Hatshepsut, while Thutmose had a son by a lesser queen, Thutmose II.

Queen Ahmose-Nefertari was the first Great Royal Wife (Queen of Egypt) to use the title "God's Wife of Amun" (each new Pharaoh was proclaimed as the son/daughter of Amun-Ra , Egypt's patron deity).