The year 1622 in science and technology included many events, some of which are listed here.

See also: 1621 in science, other events of 1622, 1623 in science and the list of years in science.

Mathematics

• English mathematician William Oughtred invents the slide rule

Births

• Adrien Auzout, French astronomer (died 1691)
• Jean Pecquet , French anatomist who discovered the thoracic duct (died 1674)

Deaths

• January 23 - William Baffin, English explorer and navigator (born 1584)